From Microsolvation to Cell Permeation: Novel Separation Science for Drug Discovery

From Microsolvation to Cell Permeation: Novel Separation Science for Drug Discovery

The development of new drugs requires extensive analysis of their physiochemical properties. Chemical analysis will include an accurate definition of the mass and structure of the target compound. It also necessitates considerable effort to determine the solubility of a given drug candidate, along with a robust assessment of how it will behave in a variety of biological environments. Of critica...

Applying science to drug discovery.

Scientists and science in the pharmaceutical industry rely heavily on the more academically orientated basic research carried out at Universities, for first of all training, but also as a source of new ideas and approaches to drug discovery. Progress in the discovery and development of novel therapeutics benefits from a healthy alliance with, and the output from, more basic research institution...

From basic science to blockbuster drug: the discovery of Lyrica.

Many great discoveries occur when they are least expected. These discoveries are most satisfying when they derive from studies of basic science. That is how the new blockbuster drug for the treatment of various neuropathic pains, epilepsy, and generalized anxiety disorder, Lyrica (pregabalin), was discovered. This essay describes the discovery and features of this new drug. One of the early pro...

A novel medium-throughput biological assay system for HTLV-1 infectivity and drug discovery

Objective(s): Here, a reporter cell line containing two reporter vectors were developed, in order to monitor the Human T-Lymphotropic Virus type1(HTLV-1) infectivity and the cell viability simultaneously. Materials and Methods: The reporter cell line was constructed by stably transfected baby hamster's kidney cell line (BHK-21), with the genomes expressing two different reporters in separate pl...

***Removed from the Issue*** Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development